Diabetes is a chronic medical illness characterized by the body’s inability to control blood sugar (glucose) levels. There are two primary types:
Type 1 diabetes is an autoimmune disorder in which the immune system targets insulin-producing beta cells in the pancreas. This results in little or no insulin production. It usually appears in childhood or adolescence and requires lifelong insulin therapy.
Type 2 diabetes is a metabolic condition in which the body grows resistant to insulin or produces insufficient insulin. It is more common in adults and has been linked to obesity, physical inactivity, and genetics. Lifestyle adjustments (diet and exercise) are used in conjunction with oral medicines and, in certain cases, insulin.
Researchers inserted a restricted number of human beta cells into lab mice and treated them with harmine and GLP1 receptor agonists.
Despite substantial advances in medical research over the last few decades, diabetes remains one of the major causes of death globally. Currently, there is no cure for the condition.
However, evidence from a newly published study by Science Translational Medicine has shown that a new innovative pharmacological therapy has the ability to greatly expand insulin-producing cells – by up to 700% – in just three months, says the report .The findings were obtained after doing research on mice with both type 1 and type 2 diabetes. Harmine and GLP1 receptor agonists were employed to treat the lab mice after the researchers inserted a restricted number of human beta cells into them.
This groundbreaking discovery has given millions of diabetics a new ray of hope for a possible cure. Beta cells in a functioning pancreas produce insulin, which aids in blood sugar regulation.
In diabetics, these cells are either destroyed or ineffective, resulting in low insulin production.Dr. Adolfo Garcia-Ocana, the study’s corresponding author, stated that this is the first time that a pharmacological therapy has been shown to raise human beta cell counts in vivo.
“We have achieved a groundbreaking discovery by successfully producing a pharmacological treatment that increases adult human beta cell counts in the body. “This breakthrough offers new hope for regenerative therapies that could potentially treat the millions of people living with diabetes around the world,” he said.
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