Can Excess Protein Make You Sick? 5 Warning Signs

High-protein diets, sometimes known as paleolithic diets, are popular. Scientists at the University of Geneva (UNIGE) used mouse models to investigate their impact. These diets, while beneficial in weight management and diabetic stabilization, are not without dangers. Excess protein significantly increases ammonium generation, which overwhelms the liver. 

Type 2 diabetes is a metabolic disorder that is rapidly rising. Due to a sedentary lifestyle and an overly rich diet, the injured pancreas struggles to regulate blood sugar levels. Current medications assist in managing the disease’s course, but they do not cure diabetes. Losing weight is frequently a crucial component of the treatment.

“Diets rich in animal and/or plant proteins, known as paleolithic diets, can be used to stabilize type 2 diabetes and regulate weight,” explains Pierre Maechler, full professor in the Department of Cell Physiology and Metabolism at the UNIGE Faculty of Medicine, who led this study.  

These diets draw inspiration from pre-agricultural meat-based diets.But how do they affect the body? Are they harmless?

Liver under pressure

Ammonium is a natural waste product of protein breakdown that is primarily removed in the liver by the enzyme glutamate dehydrogenase (GDH). When there is a protein overload, the GDH enzyme is put under stress. To investigate the effects of high-protein diets, Pierre Maechler’s team fed healthy mice and mice without the GDH enzyme in their liver a diet with protein content similar to the so-called paleolithic diet.  

5 Warning Signs:

• High protein consumption can cause digestive issues like constipation, bloating, and gas, as it lacks fiber. Reevaluating protein intake and consuming fiber-rich foods can help. 
• High protein intake can strain kidneys, especially in preexisting conditions. The kidneys must work harder to eliminate byproducts, leading to kidney damage or worsening existing issues. Monitoring protein consumption is crucial for kidney health.  
• High-protein diets can lead to dehydration due to increased urine water loss, causing symptoms like dark urine, dry mouth, dizziness, and fatigue.  
• Overemphasizing protein can lead to nutrient deficiencies, neglecting other essential nutrients. A well-rounded diet, including vegetables, fruits, whole grains, and healthy fats, is crucial for overall health, ensuring a balanced intake of nutrients.  
•  Excessive protein consumption can lead to weight gain due to calorie content and fatty protein sources. To maintain a healthy weight, balance protein with carbohydrates and fats, as excess can lead to weight gain.  

Protein is essential for a healthy diet, but overconsumption can cause digestive issues, kidney strain, and nutrient imbalances. Maintain a balanced diet with adequate protein, and consult a healthcare professional for personalized advice.  

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Source: TOI